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language model (LLM)-based genome design tools with bioprocess engineering to create next-generation therapeutic conjugative plasmids. These engineered plasmids will be optimised for industrial-scale
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guidelines for the design of improved organic materials. Interested candidates may want to take a look at our recent work: https://www.nature.com/articles/s41467-022-30308-5 & https://www.science.org/doi
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PhD Studentship: Nanopore Technology for Rapid and Accurate Measurement of Antibiotic Concentrations
for small-molecule sensing. By engineering nanopores with molecular recognition elements such as DNA aptamers, this project will enable multiplexed, real-time detection of diverse antibiotics, supporting both
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chemistry and nanoscale structure, these coatings will offer long-term, biocompatible protection against infection. The project will involve materials design, fabrication, characterisation, and biological
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. Synthetic analogues will be developed and screened alone and in combination with existing antimicrobials. The ultimate goal is to design novel chemotherapeutic combinations that disrupt cell wall remodelling
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). Design and fabricate patterned surfaces optimised for enzyme immobilisation. Assess synergistic antibiofilm efficacy under static and dynamic (flow-based) biofilm models. Apply advanced microscopy, protein
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rather than the structured biofilms found in real-world environments. This project investigates how engineered surface topographies influence HGT dynamics, aiming to develop design principles for materials
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could be applied in biotechnology, healthcare, and environmental contexts. Employ synthetic and molecular biology tools to design and test new methods of controlling fungal behaviour. Impact and Outlook
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an academic that has supervised previous work, projects or similar), A short research proposal using this template: https://www.overleaf.com/read/bffndqvvkzcv#a53b9d (this template can be copied or downloaded
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-penetrating capabilities Evaluate delivery efficiency in cell-based models mimicking lung and immune tissues Identify structure–function relationships to inform rational design of future mucosal delivery