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Supervisors: Dr. Michele Crotti Dr. Martyna Michalska Abstract: Biofilm-associated infections account for nearly 80% of human microbial infections and are notoriously resistant to antibiotics and disinfectants. With antimicrobial resistance (AMR) on the rise, there is an urgent need for...
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PhD Studentship: Nanopore Technology for Rapid and Accurate Measurement of Antibiotic Concentrations
for small-molecule sensing. By engineering nanopores with molecular recognition elements such as DNA aptamers, this project will enable multiplexed, real-time detection of diverse antibiotics, supporting both
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. Interested candidates may want to take a look at our recent work on machine learning molecular dynamics: https://www.nature.com/articles/s41467-024-52491-3 Project 2: Non-adiabatic Molecular Dynamics
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an academic that has supervised previous work, projects or similar), A short research proposal using this template: https://www.overleaf.com/read/bffndqvvkzcv#a53b9d (this template can be copied or downloaded
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mycobacterial infections. The student will characterise their mechanisms of action using cross-linking mass spectrometry and assess their effects on mycobacterial membrane integrity and cell wall metabolism
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on recent advances in recombinant RNAP production, cryo-EM structural elucidation, and fragment-based screening, the project will integrate fluorine-based NMR spectroscopy with active learning algorithms and
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for developing new treatments against drug-resistant infections. Their rapid action and ability to target bacteria in several ways make it difficult for antimicrobial resistance to emerge. Despite this promise
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. This project will use large-scale metagenomic mining to uncover novel phage-host associations and identify phage-encoded enzymes, such as endolysins, with antibacterial activity. By integrating evolutionary
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Research Environment Volpe Lab: Experts in active matter, microscopy and microfabrication, with a strong interdisciplinary focus. Ciric Lab: Leaders in healthy infrastructure and microbial surface
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-of-the-art analytical and fabrication facilities at UCL Chemistry and the Royal Institution. Both supervisors are active in national and international scientific communities, providing excellent networking and