44 evolution "https:" "https:" "https:" "Multiple" "I.E" positions at Newcastle University
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principles. The proposed project will investigate the development of TCRs by studying the impact of geometries and microstructures on the hydrodynamics of reactants in chemical and/or catalytic reactions and
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formation, compromising the enhancements achieved through the use of TC intensification principles. The proposed project will investigate the development of TCRs by studying the impact of geometries and
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(LCMS, NMR) new covalent warheads with suitable reactivity and stability for application to lysine-TCI development in drug discovery. These optimised warheads will be incorporated into known inhibitors
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to enhance both accuracy and computational efficiency, enabling near real time water quality forecasting. This development will provide a more reliable, science-based foundation for environmental decision
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. Methodology The PhD will be divided into 3 work packages (WP): WP1 - Digital Twin Development: This WP focuses on building physics-informed digital twins for high-impact use cases: Smart Grids (simulating load
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to the discovery of new medicines is the time taken to design, synthesise and test compounds through multiple cycles of optimisation. You will seek to develop an approach to reduce that time through development
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testing potential drug candidates in high-throughput. One of the barriers to the discovery of new medicines is the time taken to design, synthesise and test compounds through multiple cycles of optimisation
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complex genomic abnormalities (e.g. isochromosomes) are observed within multiple cancer types, but prognostically are thought to play different roles across different cancers. The application of long-read
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to lysine-TCI development in drug discovery. These optimised warheads will be incorporated into known inhibitors and tested against the relevant protein as a proof of concept. This is an opportunity to join a
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to address climate change. To bridge this gap, this project will characterise wildfire charcoal from historic fires with known ages (years to decades to 174 MA old) to examine compositional evolution and