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) are the sentinel of the immune system. DCs are developmentally and functionally heterogeneous and encompass multiple subsets including XCR1+ IRF8+ DCs, and a variety of IRF4+ DCs (DC2As, DC2Bs, DC3s) and
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functionally heterogeneous and encompass multiple subsets including XCR1+ DCs, and a variety of IRF4+ DCs (DC2As, DC2Bs, DC3s) and plasmacytoid DCs. DCs are short-lived cells continuously developing from
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an integrative approach that combines advanced multiomics, spatial transcriptomics, and structural biology with physiological assessments. By selectively perturbing key gene expression programs during homeostasis
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