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! Throughout the project, there will be multiple opportunities for cooperation with internal and external partners, supervising Master students, giving oral presentations at conferences, writing high-impact
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, sample and data analysis and write-up of results for scientific publication are part of the PhD process – a journey to become an independent researcher! Throughout the project, there will be multiple
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– a journey to become an independent researcher! Throughout the project, there will be multiple opportunities for cooperation with internal and external partners, supervision of Master students, giving
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Modifications The successful candidate will: Analyze and integrate multiple sequencing data types (DNA-seq, ChIP-seq, RNA-seq, Methyl-seq, DRIP-seq) to study nucleic acid modifications and related epigenetic
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will analyze epigenetic profiles in premature ageing embryos by Next Generation Sequencing, to understand the molecular network involved in these phenotypes. You will learn to analyze these Big Data by
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enabling HTP identification of interacting protein regions using pooled fragment screens and sequencing as readout. Identified interacting regions will be further validated with site-directed mutagenesis and
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perturbation of multiple metabolic genes at the single-cell level. Determining the impact of metabolic gene perturbation on T-cell subsets at different ages by employing single-cell RNA sequencing (scRNA-seq
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will make use of sophisticated mouse genetic systems, single cell sequencing and high dimensional flow cytometry as well as multiple cellular and molecular methods used in the lab. If you are interested
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. This mechanism is driven by small non-coding RNAs (piRNAs) that help to guide the effector proteins to their targets in a sequence specific manner. Hence, deciding which RNAs will be turned into piRNAs is a
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? Approach: You will employ quantitative DNA-RNA immunoprecipitation sequencing to map the locations and frequencies of specific DNA modifications within R-loops across various genomic contexts. You may test