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for up to two academic referees In case of any troubles with the e-application, please contact Petra Linhartová (petra.linhartova@ceitec.muni.cz ). Where to apply Website https://jobrxiv.org/job/phd
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of any troubles with the e-application, please contact Petra Linhartová (petra.linhartova@ceitec.muni.cz ). Where to apply Website https://jobrxiv.org/job/two-phd-candidates-students-in-molecular
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architecture and differentiation contexts. The PhD candidate will develop protocols for isotope labeling, sample handling, and NMR acquisition in stem cell-derived 3D tissues. Recommended literature: Theillet FX
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Supervisor: prof. RNDr. Robert Vácha, PhD. Topic title: Designing Coiled-Coil Peptides for Controlled Membrane Fusion and Intracellular Delivery Annotation: Most approved drugs act on cell-surface targets
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Supervisor: prof. RNDr. Robert Vácha, PhD. Topic title: Overcoming the Endosomal Barrier: Design Principles of Fusogenic Proteins for Lipid Vesicles Annotation: Cancer remains one of the leading causes
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to targeted therapy. Recommended literature: Hoferkova E, et al…. Mraz M. Stromal cells engineered to express T cell factors induce robust CLL cell proliferation in vitro and in PDX co-transplantations
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microenvironmental interactions of CLL. We will decipher the molecular functions of these lncRNAs using biochemical and cellular approaches and via a novel lncRNA knock-out mouse model. We have engineered mice
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microenvironment shapes transcriptional and genetic heterogeneity in chronic lymphocytic leukemia. Blood Advances 2022 https://pubmed.ncbi.nlm.nih.gov/35358998/ Hoferkova et al. Stromal cells engineered to express T
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. 2012; 24(6):634-9. https://pubmed.ncbi.nlm.nih.gov/22960555/ Research area: Cancer biology Keywords:CLL, microenvironment, CD20, BTK/PI3K inhibitors Funding for the PhD candidate: In the academic year
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), which establishes and maintains transcriptionally silent chromatin states. This PhD project aims to investigate how structural and biochemical features of these Polycomb proteins determine their