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-the-endosomal-barrier-design-principles-of-fusogenic-proteins-for-lipid-vesicles/t11640 Where to apply Website https://www.ceitec.eu/overcoming-the-endosomal-barrier-design-principles-of-fus… Requirements
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the rational design of delivery systems for biotechnological and therapeutic applications. Recommended literature: Blasco S.; Sukeník, L.; Vácha, R.: Nanoparticle induced fusion of lipid membranes
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for understanding G4/ i-Motif biology in fine-tuning gene expression and alleviating associated cellular dysfunctions. The design of peptide-based G4/i-Motif inhibitors can be used in (a) epigenetic-driven anticancer
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in a highly translational research environment. Open access to CEITEC MU core facilities (https://www.ceitec.eu/core-facilities/ ) with state-of-the-art equipment and experienced staff members. Our
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literature: Sandova V et al. IL4-STAT6 signaling induces CD20 in chronic lymphocytic leukemia and this axis is repressed by PI3K delta inhibitor idelalisib. Haematologica. 2021;106(11):2995-2999. https
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targets for therapy. Recommended literature: Zeni and Mraz LncRNAs in adaptive immunity: role in physiological and pathological conditions. RNA Biol. 2021 May;18(5):619-632. https://pubmed.ncbi.nlm.nih.gov
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the CXCR4/SDF-1 axis. Blood. 2016 Sep 22;128(12):1609-13. doi: 10.1182/blood-2016-04-709519. Epub 2016 Aug 1. PMID: 27480113 Free PMC article Kipps et al. Chronic lymphocytic leukaemia. Nat Rev 2017 https
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references: 1) A. Sasukimar et al. Supramolecular covalency of halogen bonds revealed by NMR contact shifts in paramagnetic cocrystals. Chem. Sci. 2025, 16, 20239-20244. https://doi.org/10.1039/D5SC05769H . 2
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and data analysis is desirable. Information about the supervisor: 2 PhD students 2 absolvents Supervisor´s personal webpage https://www.ceitec.eu/dalibor-blazek-ph-d/u25918 Research group info https
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literature: Beekman et al. The reference epigenome and regulatory landscape of chronic lymphocytic leukemia. Nature Medicine 2018 https://pubmed.ncbi.nlm.nih.gov/29785028/ Sun et al. The immune