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involved in pathobiological processes and the development of genetic instability-driven conditions, rendering them a fascinating subject within structural biology. This project will integrate ¹⁹F NMR and
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some of the characteristics of the natural microenvironment based on coculture of malignant cells with T-lymphocytes or stromal cell lines as supportive cell, but they also have specific limitations
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processivity of RNA Polymerase IIat core DNA replication genes. Apart from the C-terminal domain of RNA Polymerase II, other cellular substrates of CDK12 are not known. In this research, we propose using a
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literature: Beekman et al. The reference epigenome and regulatory landscape of chronic lymphocytic leukemia. Nature Medicine 2018 https://pubmed.ncbi.nlm.nih.gov/29785028/ Sun et al. The immune
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receptor (BCR) signaling and B-T cell interactions. Human genome contains large numbers of lncRNAs that can regulate various physiological cellular processes or contribute to the onset or aggressiveness
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references: 1) A. Sasukimar et al. Supramolecular covalency of halogen bonds revealed by NMR contact shifts in paramagnetic cocrystals. Chem. Sci. 2025, 16, 20239-20244. https://doi.org/10.1039/D5SC05769H . 2
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. Annotation: Protein-DNA interactions are critical in cellular processes and genetic instability-related conditions, particularly involving G-quadruplexes (G4) and their complementary C-rich sequences (i-Motif
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time Department: CEITEC MU and Dept of Internal Medicine, Hematology and Oncology Supervisor: Prof. Marek Mraz, MSc., M.D., Ph.D. Topic title: RNA REGULATORY NETWORKS IN AGGRESSIVENESS OF B CELL
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Axis Regulates Homing Capacity and Tonic AKT Activity in Chronic Lymphocytic Leukemia. Blood 2021 March (epub). https://pubmed.ncbi.nlm.nih.gov/33786575/ Pavlasova G, et al…. Mraz M. Ibrutinib inhibits
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membranes Excellent track record Good English language – spoken and written Motivated person with collaborative mind set Information about the supervisor: Current group: 9 postdocs, 3 PhD students,2 Master