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) J. Novotny et al. Paramagnetic Effects in NMR Spectroscopy of Transition-Metal Complexes: Principles and Chemical Concepts. Acc. Chem. Res. 2024, 57, 1467-1477. https://doi.org/10.1021/acs.accounts
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and data analysis is desirable. Information about the supervisor: 2 PhD students 2 absolvents Supervisor´s personal webpage https://www.ceitec.eu/dalibor-blazek-ph-d/u25918 Research group info https
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). Due to the composite viscoelastic environment in living cells, the polymorphism is highly complex, featuring dynamic conformational equilibrium between several folded and unfolded sub-populations driven
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complex biological systems. Building on this foundation, the proposed project aims to take a critical step forward by developing and applying in-cell NMR spectroscopy in 3D human organ models derived from
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changes in gene expression. Such memory is provided by epigenetic DNA or histone modifications. In plants, VEL proteins are accessory components to the histone-modifying Polycomb Repressive Complex 2 (PRC2