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are not curative. To enhance their efficacy, BTK/PI3K inhibitors are commonly combined with anti-CD20 monoclonal antibodies. We suppose that BTK inhibitors (BTKi) disrupt the regulation of CD20
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fusion and intracellular cargo delivery. Using a combination of coarse-grained molecular dynamics simulations with the Martini force field and complementary biophysical approaches, we will elucidate
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for understanding resistance mechanisms to BCR inhibitors, pre-clinical development of novel drugs and their combinations (several patents submitted by the lab). Recommended literature: Seda et al….Mraz FoxO1-GAB1
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this project will be to elucidate how VEL polymerization properties influence epigenetic silencing dynamics in the regulation of cold-induced flowering (vernalization). The research will combine