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will focus on developing fluorine NMR methodologies to unravel the nucleic acid conformational landscapes. G-quadruplexes (G4) and i-motifs (iM) are paradigmatic non-canonical nucleic acid structures
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lymphomas are known to be dependent on diverse microenvironmental stimuli providing them signals for survival, development, proliferation, and therapy resistance. It is known that CLL cells undergo apoptosis
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MALIGNANCIES Annotation: Transcription factors (TFs) are important regulators of cell growth, development, and hematopoietic cell differentiation. Disrupting the mechanisms that are responsible for the proper
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elucidate the molecular mechanism of protein-mediated membrane fusion, establishing a framework for the rational design of fusogenic proteins. The designed proteins will enable the development of lipid
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holds transformative potential for both basic biomedical research and pharmaceutical development, enabling direct analysis of drug-target engagement, binding affinities, and structural validation in
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. The project focuses on the development of molecular strategies for the delivery of anticancer drugs using macromolecular carriers. The successful candidates will work at the interface of organic and
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of the minister of health for a usefully finished project in medical research and development 2024 (as a member of the awarded grant team leads by prof. M. Mraz), MU prorector's awards for exceptional results
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molecular biology technics. Furthermore, we developed a novel co-culture model inducing robust primary CLL cell proliferation (~50%) in vitro (Hoferkova et al, Leukemia, 2024). We aim to utilize this game
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for understanding resistance mechanisms to BCR inhibitors, pre-clinical development of novel drugs and their combinations (several patents submitted by the lab). Recommended literature: Seda et al….Mraz FoxO1-GAB1
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contract · An attractive and competitive salary · Flexible working hours · Support for further education and professional development · Benefits package: 6 weeks of paid holiday, medical insurance, financial