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models using induced pluripotent stem cell (iPSC)-derived kidney organoids. A key aspect of this work will involve integrating bioprinting and organ-on-chip technologies to create mature and
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topics. Each focuses on gene regulation – and changes that occur in gene regulation – during stem cell development and differentiation. We use mice to model pediatric malignancies. The overall goal of our
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to identify candidate disease-causing variants. You will develop model systems, e.g. genome-editing of immune or induced pluripotent stem cells (iPSC) with specific patient-derived genetic variants. We aim
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metabolism and drug transport. Examples of this include cell-based models such as induced-pluripotent stem cells, primary human hepatocytes, and clinical studies. The pharmacoepidemiological research group
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transplantation. Blood, 2024. 143(11): p. 953-966. Yoshizato T. et al., Stable contribution of lineage-restricted stem cells to steady-state human haematopoiesis. Nature Genetics, 2025. Doi: https://doi.org/10.1038
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Post-doctoral Fellow in the Department of Orthopaedics and Traumatology, School of Clinical Medicine
) to model orthopedic pathologies. Manage and perform functional studies using animal models (e.g., transgenic mice) to evaluate disease progression and therapeutic efficacy. Utilize induced pluripotent stem
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-1209; Nature, 2019, Mar; 567(7746):113-117; Cell Stem Cell, 2018, Oct 4; 23(4):557; NatureCommunications, 2017 Nov 15;8(1):1523; TheEMBO Journal, 2016 Jan 4;35(1):24-45; J Cell Science, 2015 Dec 1;128(23
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ingredients on human health outcomes. This includes designing, executing, and optimizing in vitro cell culture and microbiological experiments relevant to gut microbiome function, diabetes, lipid dysbiosis, and
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system (CNS). We aim to uncover the principles of gene expression regulation during development and repurpose them for regeneration. We use a multidisciplinary approach that involves stem cell biology
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the liver microenvironment. Experiments will utilize animal models, cell culture including induced pluripotent stem cells, and human patient samples. Required Qualifications: Applicants should hold a PhD