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Republic, announces an opening for a PhD position in the area of molecular modeling of biomolecules with a focus on molecular dynamics simulations of nucleic acids and proteins. The candidate will be involved (among
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100%, Zurich, fixed-term We would like to announce a PhD position in molecular modeling of intrinsically disordered proteins constrained by EPR, cross-linking and NMR. Proteins in disperse and
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using optical activity, provide unique information about molecular structure and behavior. The interpretation of the spectra is often a challenging process, typically involving a combination of molecular
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, biophysics Machine learning and generative AI Molecular modeling and molecular dynamics simulations LNP formulation and characterisation including e.g. small angle scattering, microscopy, single particle
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, such as molecular data (e.g. omics), imaging, electronic health care records, longitudinal patient and population registries and biobanks. To be a doctoral student means to devote oneself to a research
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progression of pancreatic diseases. This project will entail a multi-disciplinary approach involving techniques of molecular biology, cell culture, and bioinformatics as well as animal modeling studies
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• Establishing an in vitro model for therapeutic screening • High throughput screening of several promising molecular therapeutics • Conducting an in vivo study to evaluate the molecular
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against cardiac diseases. It is based on extensive preliminary work by our working group, which has demonstrated therapeutic effects of the synthetic peptide in chronic and acute heart failure animal models
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. The long-term goal is to enable targeted interventions for the right individuals, based on their lifestyle, disease trajectories, and molecular profiles. To achieve this, we will apply deep learning models
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microenvironment. Genetic deletion of GBPs in either GBM cells or TAMs reduces tumour growth and extends survival in preclinical models, highlighting their potential as dual-function therapeutic targets This project