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acids in both tissue and liquid biopsy samples will be investigated. Examples of techniques that will be used in this PhD project include DNA/RNA isolation, DNA/RNA sequencing, spatial transcriptomics
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drive neuroinflammation in synucleinopathies and other neurodegenerative diseases. The candidate will employ advanced in vivo models and spatial technologies to dissect the roles of tissue-resident
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on cancer metastasis and novel metabolic pathways. We exploit mouse models, genetic engineering, metabolomics and single cell & spatial multi-omics analysis to gain groundbreaking insights into metabolism as
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candidate will work closely with experts in food allergy, neuroimmunology, gut physiology, and computational biology to characterize immune cell responses, construct spatial maps of inflammation along the gut
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this disease and reveal the mechanisms underlying the strong cell-type specific effect of the CMT-causing YARS mutations. For this we will generate high-resolution spatial chromatin organisation, chromatin