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both chemistry and biology to explore fundamental mechanisms of genome function (http://www.balasubramanian.co.uk ). Our projects involve developing and using cutting edge technologies in chemical
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. Insights gained will inform the development of novel therapeutic strategies for HFpEF and broader cardiometabolic disease. Training & Development The successful candidate will receive broad training in
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, develop business cases and more. At the 6-month point, students progress onto their interdisciplinary PhD research project, supervised jointly by two academics from two research groups. Usually, supervisors
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to cancer biology, as well as a strong commitment of developing and using new tools to address cutting-edge questions in these fields. This studentship is embedded within the piRNA team, consisting of both
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both sites. The project sits at the interface of cell line engineering, protein science and machine learning and you will receive advanced training in these areas while developing methods to accelerate
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of our approach is the innovation of novel methods to investigate genome function. For example, we have recently developed ways to map the binding of nucleic acid-interacting drugs and small molecules
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therapy (Simpson et al. in preparation*). When these local metabolic / immunologic changes happen during pancreatic cancer evolution remains unknown. More importantly, whether these spatial changes can be
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target, since all known treatment resistance mechanisms are downstream of, and dependent on FOXA1. However, FOXA1 has been a difficult protein to study for technical reasons. We have developed a novel tool
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Ascl1 are important. We have undertaken a comprehensive discovery experiment to identify all the proteins that can physically interact with Ascl1, using a method we developed called RIME (Rapid
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studies, and misinformation and information deception-will also be considered. In the first half year, the candidate will work closely with Dr. Seaborn and senior researchers to train and gain experience