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Main description: Native mass spectrometry is an expanding structural biology tool to elucidate the function of protein complexes. Excitingly, the demand for this technology is increasing. However
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then collapses to a hetero-hexameric complex as it encounters MRG15, displacing PALB2 (and other interacting factors/complexes) to form a new MRG15/MRFAP1/nucleosome assembly of unknown function
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, large-scale biomedical datasets, including UK Biobank and the CPRD. It will integrate complex longitudinal data—including harmonized EHRs, genetics, and the novel features captured by the LLM—to generate
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This PhD project is at the intersection of electromagnetism, numerical methods, and high-performance parallel computing, with application towards the design and optimisation of integrated circuits