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mycobacterial infections. The student will characterise their mechanisms of action using cross-linking mass spectrometry and assess their effects on mycobacterial membrane integrity and cell wall metabolism
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. Interested candidates may want to take a look at our recent work on machine learning molecular dynamics: https://www.nature.com/articles/s41467-024-52491-3 Project 2: Non-adiabatic Molecular Dynamics
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-penetrating capabilities Evaluate delivery efficiency in cell-based models mimicking lung and immune tissues Identify structure–function relationships to inform rational design of future mucosal delivery
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engineering and nano/microfabrication Materials characterisation techniques Microbiology and cell culture Translational research and clinical collaboration Regulatory considerations for medical devices
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Methods Soft lithography and microfabrication to create defined surface landscapes. • Mating assays between resistant and sensitive Enterobacteriaceae strains. • Live-cell imaging and fluorescent plasmid
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flow characterisation Nanoparticle synthesis and drug delivery systems Cell culturing and in vitro biofilm modelling Collaborative research across engineering, chemistry, dentistry, and microbiology
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plasmid efficacy against WHO-priority AMR gene analogues in relevant bacterial hosts Bioprocess optimisation: Develop high-cell-density cultivation protocols in bioreactors, addressing plasmid stability
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regions (UL-CDRs) represent a unique structural class with exceptional potential for targeting otherwise inaccessible epitopes. These UL-CDRs feature a distinctive architecture comprising a β-ribbon stalk
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: Produce recombinant viral RNAP transcription complexes in insect cells Functionally characterise RNAP activity and validate assay systems Screen fragment libraries using fluorine-based NMR spectroscopy
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an academic that has supervised previous work, projects or similar), A short research proposal using this template: https://www.overleaf.com/read/bffndqvvkzcv#a53b9d (this template can be copied or downloaded