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). While mRNA vaccines have demonstrated rapid development and high efficacy, current formulations primarily protect against severe disease rather than preventing infection at mucosal entry points
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enzymes. Mapping bacterial defence systems to infer predictive features of co-evolutionary dynamics. Impact and Outlook This project will: • Advance understanding of microbial co-evolution. • Deliver a
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for engineering novel antimicrobial peptides. The findings could lead to the development of new therapeutic scaffolds with applications in infectious disease, biotechnology, and immunotherapy. The project also
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promising targets for antiviral drug development. While the COVID-19 pandemic highlighted the threat of RNA viruses, large DNA viruses such as African Swine Fever Virus (ASFV) remain underexplored despite
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for deployment in resource-limited environments. Training and Student Development: The student will gain interdisciplinary training in: Nanoparticle synthesis and characterisation Colloid and interface science
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of industry and healthcare partners, a rare opportunity to develop a highly sought-after interdisciplinary skill set that is in demand across both academia and industry. Training and Student Development
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techniques. The findings will lay the groundwork for clinical application and contribute to the development of targeted therapies for resistant bacterial infections. Approach and Methods Atomic force
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: This project aims to pioneer a sustainable approach to combating antifungal resistance by enhancing the effectiveness of existing treatments. The findings could inform the development of innovative, non
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PhD Studentship: Nanopore Technology for Rapid and Accurate Measurement of Antibiotic Concentrations
dosing in clinical settings, reducing the risk of resistance development. Its portability and multiplexing capabilities make it suitable for deployment in both high-resource and resource-limited
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, reduce the need for systemic antibiotics, and mitigate the development of AMR in oral pathogens. The approach may also be extended to other biomedical applications involving biofilm-associated infections