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enzymes. Mapping bacterial defence systems to infer predictive features of co-evolutionary dynamics. Impact and Outlook This project will: • Advance understanding of microbial co-evolution. • Deliver a
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for engineering novel antimicrobial peptides. The findings could lead to the development of new therapeutic scaffolds with applications in infectious disease, biotechnology, and immunotherapy. The project also
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promising targets for antiviral drug development. While the COVID-19 pandemic highlighted the threat of RNA viruses, large DNA viruses such as African Swine Fever Virus (ASFV) remain underexplored despite
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for deployment in resource-limited environments. Training and Student Development: The student will gain interdisciplinary training in: Nanoparticle synthesis and characterisation Colloid and interface science
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of industry and healthcare partners, a rare opportunity to develop a highly sought-after interdisciplinary skill set that is in demand across both academia and industry. Training and Student Development
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techniques. The findings will lay the groundwork for clinical application and contribute to the development of targeted therapies for resistant bacterial infections. Approach and Methods Atomic force
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: This project aims to pioneer a sustainable approach to combating antifungal resistance by enhancing the effectiveness of existing treatments. The findings could inform the development of innovative, non
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, reduce the need for systemic antibiotics, and mitigate the development of AMR in oral pathogens. The approach may also be extended to other biomedical applications involving biofilm-associated infections
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at scale. Training and Student Development: The student will gain interdisciplinary training in: Advanced molecular cloning, CRISPR-Cas systems, and genome engineering Bioreactor operation and process
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extended to other medical devices, supporting broader efforts to combat healthcare-associated infections. Training and Student Development: The student will gain interdisciplinary training in: Surface