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acid structures comprising an RNA hybrid and a displaced single-stranded DNA (ssDNA). The exposed ssDNA makes R-loops a hotspot for DNA modifications that can impact R-loop dynamics, gene regulation and
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, to how epigenetics regulates cellular identity or neural memory. Activities and responsibilities The research group of Petra Beli offers the following PhD project: R-loops are secondary DNA structures
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cytosine methylation and its oxidized derivatives (e.g., 5-formylcytosine [5fC]), play essential roles in gene regulation and epigenetic programming. These modifications can affect DNA structure, gene
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project: Regulation of alternative splicing by R-loop formation in Arabidopsis R-loops refer to RNA-DNA hybrid structures that have been linked to genotoxic stress. More recently, R-loops have also been