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the ubiquitin code in proteostasis and genome maintenance The ubiquitin system plays a key role in determining the function and fate of proteins in virtually every biological pathway, not only in protein quality
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. This mechanism is driven by small non-coding RNAs (piRNAs) that help to guide the effector proteins to their targets in a sequence specific manner. Hence, deciding which RNAs will be turned into piRNAs is a
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are the BAF complexes, very large multi-protein complexes existing in many different configurations in human cells. Their importance is highlighted by the fact that mutations in genes coding for these complexes
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