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reductions in the expression of RFC1 transcript, along with impaired RFC1 function and increased sensitivity to DNA damage from platin drugs. CRISPR/Cas9 excision of the AAGGG repeat and flanking AluSx3
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enhance recombinant protein expression. The postholder will lead on the development of an automated, high-throughput platform to rapidly screen vector constructs, assessing how component combinations
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-day running of this project. This will include assisting with the UK-wide recruitment strategy, pre-screening of potential participants who have registered on the OCTOPUS expression of interest online
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linking) processes to ensure SERG data is research-ready and fit for purpose is also a key aspect of this role. This role will be required to engage with SERG partners (particularly the EDOL team
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question such as how cell fates diverge during asymmetric cell division. In this context, the team investigates gene expression plasticity and the unequal segregation of factors, including cellular