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and Saeys teams. In this research project you will develop and apply algorithms to link clinical phenotypes of metastasis to molecular phenotypes in mouse models. It is known that metastases exhibit
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supported by a Foundation against Cancer (2025 – 2030). We have developed in vivo single-cell CRISPR technologies to screen for dozens of molecular factors in tumor-associated macrophages (TAMs) in vivo. We
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the Guilliams and the Saelens team. Research Project In this research project you will apply in vivo CRISPR screens to study the functional specialization of liver macrophages. This project is supported by an ERC
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change in identity in all other cells, often resulting in molecular states that are eerily similar to those observed in diseases. How these intercellular cascades are exactly wired is poorly understood
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, and computational biology, the student will also contribute to the integration of experimental findings with spatial and systems-level analyses of inflammation along the gut–brain axis. Position