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can feed directly into precision surgery algorithms and clinical trials. Few PhD projects offer such a clear line of sight from variant to mechanism to clinical translation. Located on the thriving
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will explore the influence of multiple copies of the stx2a toxin gene, investigate the diversity of the prophage that carry the toxin and identify additional genetic factors contributing to HUS. To do
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secondary supervisor Dr Falk Hildebrand (Quadram Institute), who is an expert in bacterial metagenomics associated with diseases such as IBD and has developed multiple tools for understanding complex
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sexually antagonistic loci across multiple studies. Validate their effects on sex-specific fitness and traits using CRISPR-Cas9 allele swaps in fruit flies. Probe underlying mechanisms, from gene regulation