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guide the axon. Question: How do neurons sense and respond to a mechanically diverse environment and how do they integrate information? Our hypothesis is that the growth cone is the specialised cellular
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ubiquitination and proteasomal degradation in the nucleus. However, whether TPL-2 plays any functional role in the nucleus is currently unknown. Published studies and preliminary data generated within the Carmody
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the effects of extreme heat and cold exposure on health outcomes in people with multimorbidity, using a combination of population-based data analysis and controlled experimental approaches. The project will
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. Techniques used: Timelapse imaging RNAseq Mathematical modelling References: James et al. 2024 REVEILLE2 thermosensitive splicing: a molecular basis for the integration of nocturnal temperature information by
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well as in liver regeneration and cancer. Leveraging publicly available spatial datasets, this project aims to develop data-informed computational modelling and systems biology framework to dissect molecular