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death and to build a species-wide tolerance atlas linking genotype to phenotype and clinical outcome. The work will provide fundamental insights into bacterial biology and identify targets for improved
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to phenotype and clinical outcome. The work will provide fundamental insights into bacterial biology and identify targets for improved therapies. You will generate and screen pooled CRISPRi libraries across
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maintenance of neuroinflammatory processes and identify molecular targets that could serve as the basis for future therapies. To that end, we combine human studies with experimental (gnotobiotic) murine models
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targeting cancer as well as metabolic, neurodegenerative, autoimmune and infectious diseases. Leveraging innovative platforms such as novel biosensors, gene switches, genetic closed-loop circuits, and