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algorithms to detect complex structural variants in humans using long DNA sequencing reads. A structural variant (SV) is a large-scale alteration in the genome that involves rearranged, deleted, or inserted
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these transcripts into protein sequence databases. Guide the development of proteogenomics through implementation of novel algorithms and computational analysis infrastructure Development of tools to support clinical
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to the advancement of precision medicine in oncology. A typical workday may involve writing and running code to pre-process sequencing data on a compute server, applying statistical models and algorithms to construct
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within tissues using our in-house developed spatial transcriptomics-based technology (Spatial VDJ). Using established and newly developed algorithms, we map B cell evolution within tissues, including class
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at the single-cell level, using tools from optimal transport, mathematical optimization, and machine learning. In addition to method development, the work includes applying and benchmarking algorithms on both