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transcription-coupled and other nucleotide excision repair–related DNA repair mechanisms (https://lanslab.eu/publications/ ). This project builds on our previous findings that persistent DNA repair intermediates
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, proteomics approaches, as well as immunohistochemistry, fluorescent in situ hybridization (FISH), and confocal imaging. Furthermore, you will use state-of-the-art in vivo noncanonical amino acid tagging (NCAT
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signalling and disease progression. The goal of the Oncode Accelerator Growth Fund project is to accelerate the development of new cancer therapies. In this PhD project, you will employ existing proteomic
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) the molecular mechanisms of how these components work together to govern dynamic regulation of specific cellular processes. Our innovative approach combines proteomics, biochemistry, and advanced imaging
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in the analyses that is being generated with the Máxima or by our international collaborators. These include, for instance, in vitro and in vivo experiments, proteomic analyses (spectral-flow cytometry