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existing in many different configurations in human cells. Their importance is highlighted by the fact that mutations in genes coding for these complexes are found in more than 20% of all human cancers and
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PhD position: Repair of DNA double strand breaks by break-induced replication repair pathway (m/f/d)
group by reconstituting BIR in vitro for both yeast and mammalian system using bulk biochemistry and single-molecule imaging (SMI) techniques, supported by cell biology. This PhD project will involve
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imaging) and the possibility to learn and apply genome-wide R-loop mapping techniques. This project will be part of the RTG on R-loop Regulation in Robustness and Resilience (4R). More information can be
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achieved via the implementation of state of the art multicolor flow cytometry analyses, imaging, omics techniques (e. g. single cell sequencing and proteomic). Theoretical and practical knowledge in