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genetic screens in Primary and cell line models of T-cell lymphomas and characterize their oncogenic dependencies, and functionally validate them using CRISPR-based genetic perturbation approaches. Through
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Description The selected candidate will join the team studying the signaling pathways responsible for the assembly of nuclear pore complexes during the cell cycle in healthy and diseased cells, in
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in cancer cell signaling. The host team has demonstrated its immunomodulatory role in cutaneous melanoma, and this project aims to evaluate its potential as a therapeutic target. o Perform xenografts
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or models in close collaboration with experimentalists. This project focuses on deciphering tumor cell plasticity, including method evaluation/development and biological interpretation of the results. In
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charge of a project . It will have to keep project management up to date directly with the project’s scientific committee. the scientific tasks will be: - Carrying out cell biology experiments (culture
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used will be based on the use of cell-free translation extracts that will allow us to assemble and purify translation initiation complexes on our model messenger RNAs. The composition of these complexes
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Transitions of Self-Organized Embryonic Systems Gastrulation is a crucial stage of embryonic development, during which an initially homogeneous tissue organizes into distinct cellular layers. Our team recently
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: interferons alpha, lambda, cross-presentation https://institutcochin.fr/projet-6-cellules-dendritiques-contre-vih-int… . The group is expert in studying interactions between human DC and HIV-infected cell
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generateing genetically modified organoids to study the mechanisms controlling the organization and cell diversification of the human cortex Where to apply E-mail stephane.nedelec@inserm.fr Requirements
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represents tissues as composed of cells whose geometry results from hydraulic equilibrium (water exchanges) and mechanical equilibrium (cell wall deformation). The work carried out has led