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novel regulators of the B cell survival, proliferation and crosstalk with other immune cells. The PhD student will further investigate this using techniques such as genome editing (CRISPR), RNA sequencing
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https://pubmed.ncbi.nlm.nih.gov/36596869/ Research area: Cancer biology Keywords: lymphoma, CLL, lncRNA, microenvironment Funding of the PhD candidate: Part-time salary (min. 0,5 FTE) on EHA grant/AZV
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-quadruplex, I-Motif, Peptide, Nuclear Magnetic Resonance, Native Mass spectrometry Funding of the PhD candidate: GACR LA grant (GF24-10605K) (PI: Lukas Trantirek) MUNI GAMU Junior star (MUNI/JS/1849/2024) (PI
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), which establishes and maintains transcriptionally silent chromatin states. This PhD project aims to investigate how structural and biochemical features of these Polycomb proteins determine their
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architecture and differentiation contexts. The PhD candidate will develop protocols for isotope labeling, sample handling, and NMR acquisition in stem cell-derived 3D tissues. Recommended literature: Theillet FX