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: https://ecrin.org/ , https://creatic.muni.cz/ The scope of your work will be: Providing expert consultation to research teams in the planning and implementation of international clinical trials
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literature: Sandova V et al. IL4-STAT6 signaling induces CD20 in chronic lymphocytic leukemia and this axis is repressed by PI3K delta inhibitor idelalisib. Haematologica. 2021;106(11):2995-2999. https
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preparation, Committed to personal development and updating of knowledge and skills, Hands-on experience in work with genetic mouse models, organoids, live cell imaging, 3D immunofluorescence will be viewed
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one of the drivers of cellular transformation and cancer development. Tumor suppressor p53 prevents proliferation of cells with damaged DNA and eliminates them either by programmed cell death or by
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cardiomyopathy. Due to the large size of full-length plectin, classical gene-replacement strategies are not feasible, necessitating alternative therapeutic approaches. This PhD project focuses on the development
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expansion of selectively advantaged hematopoietic cells, support clonal evolution, and may contribute to malignant transformation. The dissertation focuses on understanding the molecular and genetic
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lymphomas are known to be dependent on diverse microenvironmental stimuli providing them signals for survival, development, proliferation, and therapy resistance. It is known that CLL cells undergo apoptosis
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experimental evolution and study morphogenesis in C. elegans populations evolving in the lab. Importantly, our preliminary results show that this approach is feasible as we observed evolutionary adaptation
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contributes to hematopoietic decline and pre-leukemic evolution, with potential relevance for early intervention strategies. Candidate profile The laboratory of hemato-oncology is searching for a highly
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mechanistic insight into cytoskeletal targeting strategies in cancer and support the development of plectin-directed therapies. Candidate profile Master’s degree in molecular biology, cell biology, biochemistry