12 evolution "https:" "https:" "https:" "https:" "https:" "U.S" "St" uni jobs at CEITEC MU in Czech
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literature: Sandova V et al. IL4-STAT6 signaling induces CD20 in chronic lymphocytic leukemia and this axis is repressed by PI3K delta inhibitor idelalisib. Haematologica. 2021;106(11):2995-2999. https
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lymphomas are known to be dependent on diverse microenvironmental stimuli providing them signals for survival, development, proliferation, and therapy resistance. It is known that CLL cells undergo apoptosis
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MALIGNANCIES Annotation: Transcription factors (TFs) are important regulators of cell growth, development, and hematopoietic cell differentiation. Disrupting the mechanisms that are responsible for the proper
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for understanding resistance mechanisms to BCR inhibitors, pre-clinical development of novel drugs and their combinations (several patents submitted by the lab). Recommended literature: Seda et al….Mraz FoxO1-GAB1
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targets for therapy. Recommended literature: Zeni and Mraz LncRNAs in adaptive immunity: role in physiological and pathological conditions. RNA Biol. 2021 May;18(5):619-632. https://pubmed.ncbi.nlm.nih.gov
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and data analysis is desirable. Information about the supervisor: 2 PhD students 2 absolvents Supervisor´s personal webpage https://www.ceitec.eu/dalibor-blazek-ph-d/u25918 Research group info https
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regulators and non-coding RNAs. Semin Oncol. 2018 Oct;45(5-6):291-30 https://pubmed.ncbi.nlm.nih.gov/30360879/ Zeni and Mraz LncRNAs in adaptive immunity: role in physiological and pathological conditions. RNA
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elucidate the molecular mechanism of protein-mediated membrane fusion, establishing a framework for the rational design of fusogenic proteins. The designed proteins will enable the development of lipid
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holds transformative potential for both basic biomedical research and pharmaceutical development, enabling direct analysis of drug-target engagement, binding affinities, and structural validation in
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to apply Website https://www.ceitec.eu/designing-coiled-coil-peptides-for-controlled-membrane-fu… Requirements Additional Information Work Location(s) Number of offers available1Company/InstituteCEITEC