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understand the function, regulation and biology of RNA:DNA hybrids termed R-loops. R-loops are three-stranded RNA-DNA hybrids of an RNA that invades an DNA duplex and are largely formed in a co-transcriptional
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PhD project: R-loops are secondary DNA structures consisting of an RNA-DNA hybrid and a single stranded DNA that can form behind the elongating RNA polymerase II during transcription. R-loops play
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the following PhD project: R-loops are three-stranded nucleic acid structures comprising an RNA hybrid and a displaced single-stranded DNA (ssDNA). The exposed ssDNA makes R-loops a hotspot for DNA modifications
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the following PhD project: R-loops occur naturally during transcription and can have important regulatory functions, however, persistence of R-loops can have deleterious effects and result in the accumulation
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statistical data evaluation, creation of scientific programme codes using common software packages (MATLAB, Python, R) Simulation skills with e.g. molecular dynamics and alpha fold Knowledge
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modulate seedling development in a light-dependent manner. PhD project: Regulation of alternative splicing by R-loop formation in Arabidopsis R-loops refer to RNA-DNA hybrid structures that have been linked
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programming skills in one or more languages (Matlab, Python, R, C, Fortran) excellent knowledge of English (written and spoken) high degree of motivation, creativity, and flexibility ability and willingness
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-average commitment Excellent English skills Good programming skills in a high-level data science language (e.g. R/python/julia) Our offer A vibrant research community in an open, diverse and international
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biology, or a related field. Proficiency in scripting languages (e.g., Python, R), and a solid understanding of high-throughput sequencing technologies are highly desirable. Familiarity with nucleic acid
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Storing, analysing and visualizing data using coding (e.g. R, python) Presenting findings internally in lab meetings and externally at conferences Preparing research publications in peer-reviewed journals