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, and dysregulation of R-loop processing is associated with cancer and neurodegenerative diseases. We have developed an unbiased mass spectrometry-based proteomics approach to identify proteins
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programming skills are a must. Familarity with mathematical and quantiative approaches is preferable. SEBÉ-PEDRÓS LAB Chromatin | Gene Regulation |Histone Marks | Eukaryotic Evolution |Phylogeny | Proteomics
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from physical constraints and evolutionary pressures, across multiple scales — from proteins to regulatory networks. The group combines principles from statistical physics, systems biology, and
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associated with cancer and neurodegenerative diseases. We have developed an unbiased mass spectrometry-based proteomics approach to identify proteins that regulate R-loops in human cells and discovered a role
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: Nuclear mRNA export is an essential step in eukaryotic gene expression, ensuring that mature transcripts are delivered from the nucleus to the cytoplasm for translation. Multiple challenges are faced in
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, result interpretation and figure visualization on biological data of genomics, transcriptomics, proteomics, cytomics, spatial omics to identify genetic and cytometric biomarker Provide statistical
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step in eukaryotic gene expression, ensuring that mature transcripts are delivered from the nucleus to the cytoplasm for translation. Multiple challenges are faced in this process: How are mRNAs
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labeling strategies be further developed and optimized for live-cell imaging, super-resolution microscopy, and cell-specific proteomics? How do neurons, glial cells, and immune cells communicate, and how can
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in vivo and in vitro approaches to study maternal mRNA regulation across multiple levels. Zebrafish is our primary in vivo model, offering powerful genetic tools and abundant embryos for applications
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University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke Health Integrated Practice, Duke Primary Care, Duke Home Care and Hospice, Duke Health and Wellness, and multiple affiliations