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polyubiquitylation of relevant cellular proteins in a controlled and linkage-selective manner, as well as b) identify selectively modified substrates, the responsible enzymes and linkage-selective interaction partners
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: In higher eukaryotes, proteins that lack an apparent folded structure are enriched in many vital processes. The Lemke group studies intrinsically disordered proteins in vital cellular processes
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particular, I found that a P-body protein directly interacts with a translation initiation factor, suggesting the existence of a novel molecular “switch” capable of activating dormant mRNAs. Our lab combines
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description: Spatial interactions are key processes for the development and maintenance of multicellular systems. Disturbances in interactions lead to developmental disorders or diseases. In many cases
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(DSBs) in the F1 generation, where a highly enriched heterochromatin structure blocks the accessibility of homologous recombination (HR) repair machinery. This project will investigate how DNA damage in
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formation of two- and three-dimensional DNA structures which self-assemble from a number of interacting single-stranded DNA molecules. An accurate prediction of DNA structures still remains difficult, which
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processes that produce energy and raw materials. The Department of Structural Materials is looking for a PhD Student (f/m/d) in Ion Irradiation and Materials Characterization of Novel Refractory High-Entropy
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the challenge of the projects. These key technologies drive forward the energy transition and structural change in the Rhineland region. Further information on our exciting projects can be found
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structural analysis methods. A detailed analysis of the consequences of this diversification will lead to an increased understanding of the polyphilic interactions in the active site of the proteases and would
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Description The Research Training Group (in German: Graduiertenkolleg, GRK) RTG2670 “Beyond Amphiphilicity: Self-Organization of Soft Matter Via Multiple Noncovalent Interactions” in the second