8 postdoc-exercise PhD positions at International PhD Programme (IPP) Mainz in Germany
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dynamic chromatin landscape, and indeed recent studies have shown that chromatin alterations and the nuclear architecture actively contribute to the DDR and the utilization of the downstream repair pathways
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. PhD project: Analysis of antigen-presenting cells interaction with T cells across the body during central nervous system autoimmunity In the frame of this project, we will use a novel mouse system
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DNA modifications The questions underlying this project are: How do specific DNA modifications within R-loops affect their structural stability and dynamics? What is the relationship between R-loop
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precursor transcripts in zebrafish. To do so you will use a combination of genetics, genomics and proteomics. This will reveal fundamental aspects of nuclear RNA export in general, and piRNA specific aspects
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-43 in response to DNA damage, and how do they regulate TDP-43’s function in R-loop suppression and the DNA damage response? 4) Where in the genome do R-loops appear upon TDP-43 loss-of-function
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cell memory in innate immune cells. Different to the adaptive immune system, innate cells do not develop into antigen-specific long lived memory cells that can be reactivated. Instead it was found
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, it is planned to test the effects of photosynthetically active white light and genotoxic UV-B light. iii) Do mutants with altered expression of nuclear RNase H1, including gene knockouts and inducible
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the employment of the various mouse models of accelerated senescence in stromal cells or accelerated aging of the hematopoietic system, available in the host lab. Characterization of the senescent associated