16 post-doc-image-processing PhD positions at International PhD Programme (IPP) Mainz
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into chromatin in order to fit into the nucleus of a cell. The packaging further provides a regulatory layer for DNA accessibility and therefore all DNA-dependent processes, such as transcription, DNA repair
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PhD position: Repair of DNA double strand breaks by break-induced replication repair pathway (m/f/d)
) factors like UV, X-rays, ionizing radiations etc., cellular processes like hydrolysis, oxidation, alkylation, impediment to replication fork etc., can also damage DNA endogenously. Cells have evolved
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-DNA hybrids? 2) How is TDP-43 recruited to R-loops and DNA damage sites? Is the phase separation/condensation behavior of TDP-43 required for this? 3) What post-translational modifications occur on TDP
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achieved via the implementation of state of the art multicolor flow cytometry analyses, imaging, omics techniques (e. g. single cell sequencing and proteomic). Theoretical and practical knowledge in
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discovered (Musheev et al., 2022). This reversible process may be crucial for regulating DNA repair, replication, and transcription, further underscoring the importance of understanding these epigenetic
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and a disturbance of oligodendrocytes. In order to cross the BBB, the T cells must be reactivated. It is currently unknown which kind of APCs are involved in this process. A specific cell population we
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phosphorylation (OXPHOS) and other key metabolic processes influence T-cell fate decisions. Targeting these pathways could provide novel strategies to mitigate immune aging and enhance immune responses in older
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in determining the function and fate of proteins in virtually every biological pathway, not only in protein quality control, but also in processes such as genome maintenance, gene expression, and
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translocases have been shown to regulate R-loop levels in cells. In recent years, R-loops have been recognized as a major cell-intrinsic source of genomic instability, and dysregulation of R-loop processing is
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processed is poorly understood in vertebrates. This project will help address that lack of insight. PhD project: Biogenesis of small RNA precursors The basics of the piRNA system in zebrafish have been