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-ribose (PAR) to adenosine residues, which we discovered (Musheev et al., 2022). This reversible process may be crucial for regulating DNA repair, replication, and transcription, further underscoring
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this process. A specific cell population we are interested in are the endothelial cells of the blood brain barrier (BBB). It was shown before that these cells are capable of expressing MHCII and therefore could
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of neurodevelopmental disorders such as Coffin-Siris-Syndrome, Nicolaides-Baraitser-Syndrom or Autism spectrum disorder. They manifest as brain abnormalities, intellectual disabilities and other physical aberrations
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and a disturbance of oligodendrocytes. In order to cross the BBB, the T cells must be reactivated. It is currently unknown which kind of APCs are involved in this process. A specific cell population we
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discovered (Musheev et al., 2022). This reversible process may be crucial for regulating DNA repair, replication, and transcription, further underscoring the importance of understanding these epigenetic
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-Syndrome, Nicolaides-Baraitser-Syndrom or Autism spectrum disorder. They manifest as brain abnormalities, intellectual disabilities and other physical aberrations. The molecular and cellular consequences