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are three-stranded nucleic acid structures consisting of an RNA-DNA hybrid and a displaced single-stranded DNA (Allison et al., CST 3, 38-46 (2019)). They form naturally during transcription, where
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Description We are seeking a motivated PhD candidate for a PhD thesis in bioorganic chemistry, focusing on the chemical synthesis of multi-fluorescence labelled DNA and PNA conjugates, conjugation
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. Enhancers, DNA elements with binding sites for transcription factors, play a key role in this process. Recently, it has become clear that enhancer activity requires the formation of sub-micrometer-sized
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manipulation of single molecules (Cichos group, Leipzig) Nanoparticle DNA functionalization (Yang group, Princeton) Quantum dot synthesis (Snee group, University of Illinois at Chicago) We are developing