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parallel with a global decline in fertility and increased incidences of male and female reproductive dysfunction. Although the etiologies of these conditions are complex, there is increasing evidence that
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controls almost every cellular process in humans, including targeting poorly folded proteins for destruction to prevent them harming the cell. When ubiquitin signalling goes wrong, many different disease
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pathogenic variants and represent novel therapeutic targets, respectively. To this end, we will perform cutting-edge proteomics analyses on post-mortem human retinal tissues and use bioinformatics and deep
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