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multiome RNA-seq, ATAC-seq and massively parallel reporter assays (MPRAs) for unbiased genome-wide analysis for understanding the phenotypic plasticity in different cancer cell states. Work tasks The work
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). The project combines genomic, epigenomic and 3D chromatin profiling (ATAC-Seq, easySHARE-Seq, ChIP-Seq, Micro-C/Hi-C, BS-Seq/EM-Seq), massively parallel enhancer assays (ATAC-STARR-seq), and comparative
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, Micro-C/Hi-C, BS-Seq/EM-Seq), massively parallel enhancer assays (ATAC-STARR-seq), and comparative/bayesian/deep-learning analyses, with functional validation in spruce via CRISPR-Cas9 and nanoparticle
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research. The university is fully committed to and make use of national molecular bioscience infrastructures, including SciLifeLab platforms for genomics, proteomics, imaging, bioinformatics, and high
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conventional production hosts. In parallel, we design and build advanced yeast cell factories. By combining fundamental biology with cutting-edge strain engineering, our work aims to enable sustainable
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through teaching and research of high international quality. In your daily work, you have a close interaction with competent colleagues. You will process tissues harvested from hibernation models, perform
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controls almost every cellular process in humans, including targeting poorly folded proteins for destruction to prevent them harming the cell. When ubiquitin signalling goes wrong, many different disease
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compatibility that will be used to rapidly evaluate the generality of key reactions. Key reactions showing a promising generality profile will then be subjected to a reoptimization process. This is necessary
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to neuronal dysfunction and degeneration in HD. In parallel, epitranscriptomic mechanisms, particularly N6-methyladenosine (m6A) RNA methylation, have emerged as key regulators of neuronal homeostasis, but
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, bioinformatics, and biomechanical systems engineering. The successful applicant will utilize clinical research studies using MRI and Electrophysiological tools, signal and imaging processing, and statistical