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of the probes: determination of binding parameters via jump-dilution assays, progress curve analysis, eventually combined with grating-coupled interferometry. Synthesis of optimized probes: Preparation of further
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applications in molecular imaging techniques such as PET and SPECT, as well as in targeted radionuclide therapy. Within this project we investigate optimized small molecule-based ligands targeting proline
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of cancer. Research topic for this postdoc position: 1) synthetic lead optimization of inhibitors and activity-based probes for tumor-associated proteases and 2) synthetic optimization of ‘cold’ labeling
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-coupled interferometry. Synthesis of optimized probes: Preparation of further optimized GRZB probes. This will be part of follow-up applications (FWO, MSCA) of the applicant. Next to experimental research