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complementary biophysical assays on G-quadruplex- and i-Motif-forming DNA/RNA sequences to investigate their structural equilibrium, dynamics, and ligand binding interactome in vitro and in the intracellular
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. These insights will inform the rational design of coiled-coil peptide sequences with said features and assess their capacity to induce membrane fusion using Martini coarse-grained simulations. This research will
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(Hoferkova et al, Leukemia, 2024). Using kinase inhibitors, the biology of CLL and responses to targeted treatment will be interrogated. The student will utilize various functional assays, RNA sequencing
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