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. These insights will inform the rational design of coiled-coil peptide sequences with said features and assess their capacity to induce membrane fusion using Martini coarse-grained simulations. This research will
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(Hoferkova et al, Leukemia, 2024). Using kinase inhibitors, the biology of CLL and responses to targeted treatment will be interrogated. The student will utilize various functional assays, RNA sequencing
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. Annotation: Protein-DNA interactions are critical in cellular processes and genetic instability-related conditions, particularly involving G-quadruplexes (G4) and their complementary C-rich sequences (i-Motif
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novel regulators of the B cell survival, proliferation and crosstalk with other immune cells. The PhD student will further investigate this using techniques such as genome editing (CRISPR), RNA sequencing
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sequencing from paired samples of FL and transformed FL and from FL samples before and after relapse. This pointed to several candidate non-coding RNAs that will be further studied. We will also integrate
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the PhD student using technics such as genome editing (CRISPR), RNA sequencing, use of primary samples, functional studies with various in vitro and in vivo mouse models. The research is also relevant