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-epithelial crosstalk in colorectal cancer initiation, progression and therapy resistance. Using state-of-the-art single-cell RNA sequencing (scRNAseq) and spatial transcriptomics on CRC patient samples, we
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functional screens and read out mutation identities via barcode sequencing. By providing a direct link between sequence and function MAGESTIC enables massively scaled screens of precise mutations, with
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facilities (e.g., sequencing, proteomics and imaging) and extensive expertise in functional genomics, gene-regulatory mechanisms and cancer biology. This international, well-equipped, highly ambitious and
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cells to generate advanced model systems for studying beta-cell maturation and failure. You will apply state-of-the-art molecular biology and tissue culture methods, along with next-generation sequencing
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contributes to multiple peer-reviewed publications. Participates in the preparation and submission of grant applications. Develop and propose innovative research ideas, including new methods for data analysis
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available single-cell sequencing data generated from patient samples and mouse models, we will enhance and apply machine-learning based algorithms to deconvolute bulk tumor RNA-seq samples to distinct immune
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fundamental drivers of metastasis, drug resistance, and other key cancer outcomes. Projects will be tailored to the candidate’s strengths and interests, with multiple creative, high-impact directions available
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pediatric cancers. In prior work, we have developed tools and methods to map the cellular diversity of pediatric tumors by adapting single-cell sequencing techniques to archival frozen tumors. In that work
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who wish to pursue research specifically in the following areas: (1) Mouse embryo morphogenesis; (2) Mouse genetics and gene regulation; (3) Single cell RNA-sequencing with bioinformatic analysis; (4
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desirable. Experience with mouse models, genome editing, or next-generation sequencing is a plus. Excellent communication skills, critical thinking, and a collaborative mindset. A strong publication record