16 multiple-sequence-alignment PhD positions at International PhD Programme (IPP) Mainz
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: Analyze and integrate multiple sequencing data types (DNA-seq, ChIP-seq, RNA-seq, Methyl-seq, DRIP-seq) to study nucleic acid modifications and related epigenetic regulatory processes. Develop analysis
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ageing embryos by Next Generation Sequencing, to understand the molecular network involved in these phenotypes. You will learn to analyze these Big Data by bioinformatic analysis. You will work in a team
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metabolic pathways involved in T-cell aging using advanced genetic models that allow for parallel CRISPR perturbation of multiple metabolic genes at the single-cell level. Determining the impact of metabolic
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genetic systems, single cell sequencing and high dimensional flow cytometry as well as multiple cellular and molecular methods used in the lab. If you are interested in this project, please select Waisman
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contexts This project aims to fill this gap in knowledge by combining quantitative mass spectrometry-based proteomics, CRISPR/Cas genome targeting and targeted next generation sequencing technologies
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to guide the effector proteins to their targets in a sequence specific manner. Hence, deciding which RNAs will be turned into piRNAs is a crucial step. How piRNA precursor transcripts are selected and
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immunoprecipitation sequencing to map the locations and frequencies of specific DNA modifications within R-loops across various genomic contexts. You may test the impact of these modifications on R-loop stability using
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PhD position: Repair of DNA double strand breaks by break-induced replication repair pathway (m/f/d)
multiple DNA repair pathways to deal with these DNA lesions. DNA double strand breaks are one of the most complex and thus deleterious DNA lesions to repair. The major pathways used by cells to repair DSBs
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library preparation from DNA:RNA hybrid immunoprecipitation followed by sequencing) identified major changes in R-loop formation in the comparison of dark- and light-grown seedlings (Xu et al., 2020
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achieved via the implementation of state of the art multicolor flow cytometry analyses, imaging, omics techniques (e. g. single cell sequencing and proteomic). Theoretical and practical knowledge in