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functional genomics — previous experience with multiple nextgen sequencing platforms, spatial multiomics platforms, and/or a strong computational background is preferred Knowledge of aptamers, SELEX
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acquire additional skills and be involved in the analysis of single-cell RNA Sequencing, WES, and in situ transcriptomics data. Trainees will present their findings at regular lab meetings, departmental
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techniques in our laboratory, including population-scale epidemiology studies, digital pathology, genomic sequencing, and spatial transcriptomic and protein profiling. Our tissue profiling work encompasses
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novel in vivo gene therapy approaches targeting hematopoietic stem cells. You will generate data on efficacy and safety of gene therapy vectors in multiple target cells and carry on preclinical
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aims to analyse ecDNA evolution over time using single-cell RNA/ATAC sequencing and to develop a ctDNA-based approach for detecting and monitoring ecDNA to support biomarker and treatment development
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know very little about the mechanisms that align DNA replication activities to potentially harmful endogenous threats such as metabolic stress and thereby limiting the detrimental consequences
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productivity, along with excellent written and verbal communication skills. Experience with bioinformatics and programming for analysis of sequencing-based datasets (DNA, RNA, epigenetic) is highly valued
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; Gastroenterology 2025; JCI 2025). Resources and Environment The Cao lab provides access to: State-of-the-art NIH core facilities for mouse transgenics, human iPS cells, high-throughput sequencing, proteomics
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methods to diagnose and monitor childhood cancers. This may include the use of ultra-rapid RNA-sequencing for real-time diagnostics and analysis of circulating nucleic acids to monitor drug resistance
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development and regeneration. Our research combines in vivo genetic models, in vitro organoid systems, advanced imaging, and high-dimensional sequencing approaches to uncover fundamental principles by which