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Lymphoid-myeloid crosstalk and cooperation are essential for host protection against infection. Involving multiple signaling pathways, this communication is thought to involve sensing of infection by myeloid
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micropatterning of hard tissues (teeth and bones). To achieve our scientific objectives, we use comprehensive methodological approaches including single-cell RNA-sequencing, spatial transcriptomics, genetically
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fluorescence live imaging, and 3) conduct a genetic characterization of evolving populations by performing whole genome sequencing. Altogether, this interdisciplinary approach links genomic analysis and
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Access to well-equipped facilities (sequencing, imaging, animal behavior) Interdisciplinary research environment at the Bio-Medical Campus with strong international collaborations Opportunities for career
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, including metabolomics, proteomics, metabolic cages, sequencing, and advanced imaging facilities · Scientific and strategic mentoring, including guidance in project management and individual consultations
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impact. The selected candidate will work mainly with sequencing results, including data from long-read sequencing, chromatin conformation, and accessibility, toward data integration and interpretation
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This research involves mouse studies (surgery and adoptive cell transfer), wet-lab techniques (cell culture, flow cytometry and imaging), and analysis of sequencing and spatial data. The candidate is expected
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complementary biophysical assays on G-quadruplex- and i-Motif-forming DNA/RNA sequences to investigate their structural equilibrium, dynamics, and ligand binding interactome in vitro and in the intracellular
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with Western blot analysis is considered an advantage. Bioinformatics skills, including basic data processing, statistical analysis, or work with high-throughput or sequencing data, are highly welcome
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. These insights will inform the rational design of coiled-coil peptide sequences with said features and assess their capacity to induce membrane fusion using Martini coarse-grained simulations. This research will