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scrambling. These splicing processes are regulated by cis-regulatory sequences and trans-acting splicing factors (SFs). While most mRNA isoforms produced from the same mucin gene locus encode similar
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mortality rate. This project will involve a comprehensive approach combining bacterial whole genome sequencing, genomics based bio-informatics, chemical analyses of bacterial compounds and immunological
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short and long-read sequencing and transcriptomics, and iPSC-based disease modeling to better understand the genetic etiologies of intractable epilepsy. The team is part of the European STXBP1 consortium
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of CRC-associated mucin mRNA isoform signatures in predicting the optimal therapy. These research objectives will be approached using established high-throughput next-generation sequencing, molecular
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insights into molecular quenching dynamics. This fundamental research project will have potential impact in sensing concepts for multiple biomolecules, including nucleic acids, proteins, and other clinically